The Henry M. Jackson Foundation for the Advancement of Military Medicine

Advancing Military Medicine

Search Results - cancer

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Small Molecule Therapeutics for Acute Myeloid Leukemia and Solid Tumors (HJF 490-17)
A technology related to novel methods of using small molecule compounds for treating myeloid neoplasms and solid tumor is available for licensing or collaboratively developing from HJF. Applications and Advantages Novel therapeutic targets for treating AML Targeted therapy for cancer patients with overexpression or activating mutation of SETBP1 Innovation...
Published: 3/20/2026   |   Updated: 2/24/2025   |   Inventor(s): Yang (Dennis) Du, Nhu Nguyen
Keywords(s): Acute Myeloid Leukemia, AML, Cancer, Leukemia, Oncogene, SETBP1, Small Molecule, Therapeutics
Category(s): Therapeutic
Lymphocyte Antigen 6 (Ly6) Targeted Cancer Immunotherapy - (HJF 649-23)
A technology related to using antibodies, antibody-drug conjugates, and chimeric antigen receptor (CAR) transduced immune cells that selectively targets Ly6 family of proteins overexpressed in cancer cells and has the potential to be effective in treating ovarian, colorectal, gastric, breast, and lung cancer without off-target effects. This HJF technology...
Published: 3/19/2026   |   Updated: 5/6/2024   |   Inventor(s): Geeta Upadhyay
Keywords(s): Antibodies, Antibody Conjugates, Antibody Drug Conjugate, Cancer, CAR, Ly6, Lymphocite Antigen 6
Category(s): Therapeutic
Small Molecule Inhibitors of ERG Oncoprotein - (HJF 578-20, HJF 393-15, and HJF 324-13)
HJF scientists have developed a first-in-class family of novel and potent small molecule ERG inhibitors that can be used as targeted therapeutics for malignant diseases with overexpression of ERG oncoproteins. Therapeutic indications may include prostate cancer, leukemia, and colorectal cancer. Applications and Advantages First-in-class small molecule...
Published: 3/19/2026   |   Updated: 2/2/2023   |   Inventor(s): Albert Dobi, Sanjay Malhotra, Mallesh Pandrala, Binil Eldhose
Keywords(s): Cancer, Colorectal Cancer, ERG, Leukemia, Oncogene, Prostate Cancer, Small Molecule, Therapeutics
Category(s): Therapeutic
Lymphocyte Antigen 6 (Ly6) Targeted Small Molecule Therapeutics for Breast Cancer - (HJF 533-19)
A technology related to using novel small molecule therapeutics for breast cancer treatment is available for licensing from HJF. These small molecules specifically inhibit LY6K, a cancer-testis oncoprotein, in cancer cells, thus providing a novel targeted therapy for breast, colorectal, and other cancers. Applications and Advantages Targeted therapeutics...
Published: 3/19/2026   |   Updated: 2/2/2023   |   Inventor(s): Geeta Upadhyay
Keywords(s): Breast Cancer, Cancer, Colorectal Cancer, LY6K, Oncogene, Small Molecule, Therapeutics
Category(s): Therapeutic