Researchers at the Henry M. Jackson Foundation (HJF) have developed a Mouse monoclonal antibody (mAb) that that reacts specifically against the human ETS Translocation Variant 4 (ETV4) transcription factor protein. Research indicates a correlation between strong ETV protein expression and poor outcomes in several cancers. The antibody can be used to detect and identify the presence of ETV4 protein molecules in tissues, body-fluids or cell extracts.

Applications and Advantages

• Research tool selective against ETV 4
• Can be used in conjunction with immuno-histochemistry, enzyme-linked-immunosorbent-assay (ELISA)
• As a tool for detection of cancer in human tissue specimens

Innovation Description

This asset relates to a novel mouse mAb against ETV4. It reacts specifically against the human ETV4 transcription factor protein. Most of the available mouse monoclonal and rabbit polyclonal antibodies against ETV4 are raised against longer peptide epitope sequences and therefore have low specificity and low affinity.

This antibody can be used to detect and identify the presence of ETV4 protein by recognizing the epitope represented by specific amino acid sequences within the ETV4 protein.

Inventors

• Shyh-Han Tan, Ph.D., HJF

Innovation Status

Further evaluation using tissue specimens from larger cohorts to establish the sensitivity and specificity of this antibody and validate the utility of ETV4 detection in cancer detection are in progress.

Intellectual Property Status

Research Tool