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The Henry M. Jackson Foundation for the Advancement of Military Medicine
Advancing Military Medicine
Search Results - immunogen
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Filarial Intestinal Antigens as Vaccine Candidates and Testing in Novel Animal Model of Filariasis - (HJF 378-14)
Introduction Filariae are tissue-invasive parasitic nematodes that cause human diseases such as lymphatic filariasis, river blindness and African eyeworm; affecting over 200 million people worldwide. In addition to human disease, filarial parasites infect dogs and cats causing heartworm infections. Currently, no vaccine exists to prevent either human...
Published: 3/20/2026
|
Updated: 10/29/2025
|
Inventor(s):
Edward Mitre
,
Christopher Morris
,
Sasisekhar Bennuru
,
Thomas Nutman
Keywords(s):
B. malayi
,
Filarial Disease
,
Heartworm
,
Immunogen
,
Peptide
,
Vaccines
Category(s):
Research Tool
,
Therapeutic
Immunogen
s and Vaccine Compositions Against Flavivirus - (HJF 624-22)
HJF researchers have developed a novel recombinant flavivirus
immunogen
that can induce immunogenicity against multiple flaviviruses, including ZIKV (Zika) and DENV (dengue), without life-threatening antibody-dependent enhancement (ADE) responses. Mice immunized with this recombinant immunogen were protected from lethal ZIKV challenge. Applications...
Published: 7/24/2025
|
Updated: 1/5/2024
|
Inventor(s):
Shelly Krebs
,
Vincent Dussupt
Keywords(s):
Dengue
,
Flavivirus
,
Immunogen
,
Vaccines
,
Zika
Category(s):
Therapeutic
,
Diagnostic
,
Research Tool
